Christie adapted Ten Little Indians for the stage. It first played with the novel's original title, Ten Little Niggers, in London, opening October 17, 1943; it was produced under the title Ten Little Indians on Broadway and opened at the Broad-hurst Theatre on June 27, 1944.

The novel was made into three film versions, all titled Ten Little Indians. The first (1966) was directed by George Pollock and starred Hugh O'Brian and Shirley Eaton. The second (1974) was directed by Peter Collinson and starred Oliver Reed and Richard Attenborough. The third (1989) was directed by Alan Birkinshaw, starring Donald Pleasence and Brenda Vaccaro.