The primary setting of “Spring and All” is the road on which the speaker is traveling while he makes his observations about Spring. Though the first line of the poem does reveal the destination of the road, “the contagious hospital," the road still takes on the marginal meandering quality of a space with an uncertain end through the structure of the poem on the page. The varying line length and stanza length and the frequent use of enjambment even between different stanzas creates the effect of an uneven and winding road on which the speaker proceeds at an unsteady pace while thinking about what he sees in a manner that also proceeds in fits-and-starts. This flexibility mirrors the sense of uncertainty associated with the speaker’s thoughts as he creates new meaning from his visual observations.