A silent, black and white version of "The Red-Headed League" was filmed in 1921 for a series, The Adventures of Sherlock Holmes. This version was produced in Britain by Stoll Picture Productions and stars Eille Norwood as Holmes and Hubert Willis as Watson.

"The Red-Headed League" was adapted in 1954 for a British television series of Sherlock Holmes's cases, starring Ronald Howard as Holmes. It appears on videotape along with the story "The Deadly Prophecy" from Nostalgia Family Video.

With Jeremy Brett as Holmes, "The Red-Headed League" appeared in the 1985 PBS series, The Adventures of Sherlock Holmes (second series). This adaptation was produced in Britain by Granada Television.