A television series based on Kennedy's book was produced by Robert Saudek Associates in 1964. It won the 1965 Peabody Award, a prize recognizing outstanding achievement in television. The series starred Walter Matthau, Burgess Meredith, and Carroll O'Connor.

In 1989, Caedmon Audio Cassettes released an audio adaptation of Profiles in Courage. The narrator for this audio version was Kennedy's son, John F. Kennedy Jr.