The Odd Couple was adapted by Simon himself as a 1968 film starring Walter Matthau as Oscar and Jack Lemmon as Felix. Gene Saks, who directed the stage version, also directed the film which is very faithful to the play script, though occasionally expanded to include street scenes in New York City. In technicolor, running 106 minutes, available from Paramount Home Video and at many video rental stores. A videodisc (Laservision) version is also available from Paramount.

An animated cartoon called The Oddball Couple premiered in September of 1976 on ABC and was based on the odd couple concept as it featured a slob-like dog named Fleabag and a fussy cat named Spiffy, both freelance magazine writers.

The Odd Couple was adapted as a 30 minute television show that ran on ABC from September of 1970 to July of 1975 and included 114 episodes. Jack Klugman played Oscar and Tony Randall played Felix, but...