"No Humans Involved" unveils the world of spiritualist Jamie Vegas who has to save the ghosts of murdered children while staring in a television show called "Death of Innocence", where she is to raise the ghost of Marilyn Monroe.

At the same time, we follow an occult group who tries to uncover the secrets of dark magic through killing mostly children.

Jamie realizes that she hears voices and is being touched by ghosts. Something like that never happened to her before. She needs to investigate it along with her friend Jeremy Danvers who is a werewolf and her friend Eve, who is a ghost. She can speak to ghosts and she can also see them.

Through contacts and inquiries she makes, such as through Interracial Council, she manages to find out about other groups that trace scams in paranormal events or report on them. Eventually they discover an occult group that uses hard core sex to uncover magic.

Jaime who is love with Jeremy Danvers manages to escape various dangerous situations, such as when escaping from the shop owned by Botnick, who also knows about the group who researches a truly powerful magic.

She decides to find the dead bodies of the children buried in the garden, near the location where her show is recorded. She suspects someone is using dark magic that drains them off their energy. The ghosts of these children are unable to cross over, being endlessly trapped on earth. Her performance is publicized and some bodies of dead children are discovered.

May Donovan, a lawyer who is part of Weiss Society, deals with scams involving paranormal events turns out right after the event. Jaime and others began suspecting that she may be involved in the group that deals with dark magic.

They decide to investigate it. Jeremy and another werewolf, Karl go to meet a journalist, Zack Flynn who belongs to Erich Weiss Society as well. Jamie and Hope, a half-demon remain in the hotel, guarding against the meeting of the members of the occult group.

Hope is lured into the garden sensing that someone has been murdered there and Jaime follows her despite the warnings of her ghost friend, Eve. Suspecting that Hope may be part of the set up, Jaime hits her in the head, and she falls unconscious. Soon after also Jaime falls unconscious, waking up in a concrete box inside the room. There are two other ghosts with her as well and Hope, who remains unconscious.

She finds that the ghosts that are nearby belong to those murdered by the occult group. She also learns that they burn the bodies after casting a binding spell that weakens bodies, making a person unable to move.

The group with May Donovan as a leader walks inside the room. They prepare Hope and Jaime for burning. Jaime tries to distract them first revealing that May lied about the necessity to kill one of their members. She then raises the bodies of the dead animals inside the room who attack the group members. Jaime manages to escape. Her friends, Jeremy, Karl and Eve finally show up, dealing with the clean up of the dead bodies that remain in the killing room.

Jaime releases the spirits of the children buried in the garden. She decides to quit her TV career while dealing with her new relationship she commenced with Jeremy.