Neuromancer is the first book in Gibson's Sprawl (or Matrix) trilogy.

Count Zero (1986) and Mona Lisa Overdrive (1988) complete the series. Certain characters like Molly and the Finn recur, but the novels are independent works. Molly reappears under the alias Sally Shears in Mona Lisa Overdrive and plays a central role in that novel. Certain characters like Case make only brief appearances in later novels. The characters of Angie Mitchell and Bobby Newmark, introduced in Count Zero, reappear in Mona Lisa Overdrive. The trilogy is also related to Gibson's early story, "Johnny Mnemonic." In Neuromancer Molly refers to a friend named Johnny who was killed by the Yakuza.

The novels can be read separately without relying on previous information, but familiarity with Gibson's style and previous settings and characters helps make reading the later novels less confusing.