Compare and contrast the sister relationships of the following: Anna and Kate, Sara and Suzanne, Julia and Isobel.

Campbell and Kate both have medical conditions that are important in the book. Discuss how these medical conditions impact those around them. How do Campbell and Kate cope with their conditions?

Parents have conceived babies to help their sick siblings in real life. Not so long ago, this would not have been possible. Discuss designer babies and how the fertility industry can help or hurt people.

Discuss the ways Anna and Kate try to be normal teenagers. How are their lives different from those of their peers?

Why does Kate only have one chapter at the end? Why does the reader not get her perspective during her illness and Anna's hearing?

The media coverage of Sara's pregnancy and Anna's lawsuit are in the book. Do you...