The Matchmaker was made into a film by Paramount Pictures in 1958, starring Shirley Booth as Dolly Levi, Anthony Perkins as Cornelius, and Shirley MacLaine as Irene Molloy. John Michael Hayes wrote the adaptation, which was directed by Joseph Anthony.

In 1963, this play was adapted as a Broadway musical, Hello, Dolly!, with a book by Michael Stewart and music and lyrics by Jerry Herman. Carol Channing played Dolly, in a career defining performance. Hello, Dolly! ran on Broadway for 2,844 performances.