Look Homeward, Angel was adapted as a three-act comedy/drama by Ketti Frings, first produced in New York at the Ethel Barrymore Theatre in 1957. It was published by Scribner in 1958, won the Pulitzer Prize, and was adapted by Gary Geld and Peter Udell as the musical comedy Angel, performed on Broadway in 1978.

John Chandler Griffin's Memories of Thomas Wolfe: A Pictorial Companion to "Look Homeward, Angel" (1996) is a very helpful companion piece to Wolfe's novel, both as a source of contextual information and as a way of bringing the events to life.