Inherit the Wind became a film in 1960. Produced and directed by Stanley Kramer, this version is available from CBS/Fox Video. It stars Spencer Tracy as Henry Drummond, Frederic March as Matthew Harrison Brady, and Gene Kelly as the acerbic E. K. Hornbeck.

In 1965, the Hallmark Hall of Fame and George Schaefer produced a television movie version of Inherit the Wind. It starred Melvyn Douglas as Drummond and Ed Begley, Sr. as Brady. (Douglas had replaced Paul Muni during the play's original run on Broadway.)

A different television production of Inherit the Wind surfaced in March, 1988. This version starred Jason Robards in the role of Henry Drummond, Kirk Douglas as Matthew Harrison Brady, and Darren McGavin as Hornbeck.