Don’t forget my medicine.
-- Grandma (Grandma)

Importance: When George’s mother goes out shopping, she and Grandma both remind George to remember to give Grandma her medicine at eleven o’clock. George does not get along well with Grandma, and the reminder to give her medicine will ultimately lead George to creating his own medicine. Grandma’s reminder helps to set the stage for the rest of the novel.

Most grandmothers are lovely, kind, helpful old ladies, not this one.
-- Narrator (Grandma)

Importance: Here, the narrator explains why George does not get along well with his grandmother. Grandma, it turns out, is not a sweet old woman, but someone very bossy, grumpy, and selfish. At the same time, Grandma is only ever unkind to George when his mother and father are not around.

A magic medicine it shall be!
-- George (The Marvelous Plan)

Importance: George hates Grandma, and decides he is going to take her on. He decides he is...