The Effect of Gamma Rays on Man-in-the-Moon Marigolds was presented in an abridged version as a television play in 1966. It was produced by National Educational Television and was presented as part of its New York TV Theatre series.

The Effect of Gamma Rays on Man-in-the-Moon Marigolds was adapted as a film in 1972 for Twentieth Century-Fox. This version was produced and directed by Paul Newman. The screenplay is by Alvin Sargent. It stars Joanne Woodward as Beatrice.