The Front Page was adapted as a film in 1931. It was directed by Lewis Milestone and produced by Howard Hawks. It starred Pat O'Brien as Hildy and Adolphe Menjou as Walter Burns.

A version was filmed in 1940 by director Howard Hawks under the title Girl Friday. It featured Rosalind Russell as a female Hildy and Gary Grant as Walter Burns.

A television series based on the play was produced from 1949-50. It starred John Daly as Walter Burns and Mark Roberts as Hildy.

Another version was filmed in 1974. Directed by Billy Wilder, the movie starred Walter Matthau as Walter Burns and Jack Lemmon as Hildy.