Mary Shelley made an anonymous but powerful debut into the world of literature when Frankenstein, or The Modern Prometheus was published in March, 1818. She was only nineteen when she began writing her story. She and her husband, poet Percy Bysshe Shelley, were visiting poet Lord Byron at Lake Geneva in Switzerland when Byron challenged each of his guests to write a ghost story

Settled around Byron's fireplace in June 1816, the intimate group of intellectuals had their imaginations and the stormy weather as the stimulus and inspiration for ghoulish visions. A few nights later, Mary Shelley imagined the "hideous phantasm of man" who became the confused yet deeply sensitive creature in Frankenstein. She once said, "My dreams were at once more fantastic and agreeable than my writings." While many stage, television, and film adaptations of Frankenstein have simplified the complexity of the intellectual and emotional responses of Victor Frankenstein and his creature to their world, the novel still endures. Its lasting power can be seen in the range of reactions explored by various literary critics and over ninety dramatizations.

Although early critics greeted the novel with a combination of praise and disdain, readers were fascinated with and a bit horrified by the macabre aspects of the novel. Interestingly, the macabre has transformed into the possible as the world approaches the twenty-first century: the ethical implications of genetic engineering, and, more recently, the cloning of livestock in Scotland, find echoes in Shelley's work. In addition to scientific interest, literary commentators have noted the influence of both Percy Shelley and William Godwin (Mary's father) in the novel. Many contemporary critics have focused their attention on the novel's biographical elements, tracing Shelley's maternal and authorial insecurities to her very unique creation myth. Ultimately, the novel resonates with philosophical and moral ramifications: themes of nurture versus nature, good versus evil, and ambition versus social responsibility dominate readers' attention and provoke thoughtful consideration of the most sensitive issues of our time.