The original short story version of Flowers for Algernon was adapted for television as The Two Worlds of Charlie Gordon for CBS Playhouse in 1961.

The novel Flowers for Algernon was made into the feature film Charly in 1968, Cliff Robertson won the Academy Award as Best Actor for his portrayal of Charlie Gordon, available from CBS/Fox Home Video.

The novel has also been presented on the stage, David Rogers adapted the novel as a two-act play, Flowers for Algernon, in 1969; a dramatic musical, Charlie and Algernon, was first produced in Canada in 1978 and played on Broadway in 198O, Stage plays based on the novel have also been produced in France, Australia, Poland, and Japan.

Flowers for Algernon has also been adapted for radio: as a monodrama for Irish radio in 1983, and as a radio play in Czechoslovakia in 1988.