The following version of the book was used to create this study guide: Pilkey, Dav. Cat Kid Comic Club. Scholastic Press, New York, NY, 2020. Kindle AZW file.

Lil' Petey, whose alter-ego is Cat Kid, loves to draw and write comics. He wants to share his love with his friends, the frogs. So, he begins a comic club. His friend Molly, who is a tadpole, takes the role of vice-president for the club. The announcement begins a huge argument because everyone sees that as an important task that they all want to do. The frogs' dad, a fish named Flippy, puts an end to the arguing. Flippy becomes too invested in the process. As the youngsters begin to produce their comics, Flippy feels the material is inappropriate and tries to make them conform to his ideas.

Meanwhile, Lil' Petey encourages everyone to try. He tells them to list things that interest them. But, he discovers most of the frogs cannot come up with an idea. Then, they feel like they do not draw or write well enough. Lil' Petey challenges them all to fail, feeling this would be a way to ensure they at least try. The resulting comics are ridiculous, but generally funny. Lil' Petey points out they have accomplished something with their efforts.

Lil' Petey helps them realize they can use poetry instead of dialogue and photography instead of drawing. By the time the novel comes to an end, all the frogs have produced comics, either individually or working together in groups or two or three. Flippy has learned a little more tolerance toward the ideas of the youngsters. Lil' Petey has taught the group some of the elements of a graphic novel while producing a preview for his next comic book.

All the frogs create either a graphic novel or a preview of one in progress. The characters in their stories are Supa Fail (who generally makes things worse while accomplishing any task), a toothbrush (who travels back in time to become a lawyer for dinosaurs), and Chubbs McSpiderbutt. One frog uses haiku to express her opinions on nature, and one creates characters using an array of items, such as pipe cleaners, putty, and broken toys. The frogs learn about autobiographies and end by having a party to celebrate their successes.