The book underwent several rapid printings, a testament to its popularity with the public. O'Hara had found his audience and would go on to publish books for nearly the next four decades. His peers, too, praised his freshman effort. Ernest Hemingway wrote of Appointment in Samarra: "If you want to read a book by a man who knows exactly what he is writing about and has written it marvelously well, read Appointment in Samarra by John O'Hara." Dorothy Parker, who was something of a mentor to O'Hara, pointed out that "Mr. O'Hara's eyes and ears have been spared nothing, but he has kept in his heart a curious and bitter mercy." Parker's comments reflect the acclaim given to O'Hara's descriptive flair and ear for dialogue that is especially sharp in his first novel.

Just as there were mixed reviews for Appointment in Samarra upon its release...