An overwhelmingly popular film version was released in 1984 Amadeus was directed by Milos Forman and starred F. Murray Abraham as Salieri and Tom Hulce as Mozart. Shaffer wrote the screenplay. This film is available in VHS and DVD formats.

A television version appeared IN Romania, directed by Radu Cernescu and starring Razvan Vasilescu as Mozart and Radu Beligan as Salieri. The production used Shaffer's play for the script.