In 1994 a film version of The Road to Wellville was released, which is faithful to the novel in both plot and tone. The film was produced and directed by Alan Parker, who also wrote the screenplay. Anthony Hopkins plays the part of Dr. John Harvey Kellogg, Bridget Fonda plays Eleanor Lightbody, Matthew Broderick plays Will Lightbody, John Cusack plays Charles Ossining, and Dana Carvey plays George Kellogg.

In 1993 an audio tape of The Road to Wellville was released by Highbridge Company. Ragtime music introduces Boyle reading his own novel.