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Hemophilia A and hemophilia B are genetic disorders in the blood-clotting system, characterized by bleeding into joints and soft tissues, and by excessive bleeding into any site experiencing trauma or undergoing surgery. Hemophilia A and B are clinically indistinguishable. Both have the same type of bleeding manifestations, and both affect males almost exclusively.
![The coagulation cascade involves multistep conversion of several factors into their active (A) forms. In hemophilia, factors VIII or IX are missing or present in insufficient amounts.](https://d22o6al7s0pvzr.cloudfront.net/images/bookrags/gen/gen_02_img0186.jpg)
Contrary to popular belief, individuals with hemophilia rarely bleed excessively from minor cuts or scratches. Hemophilia A and B are both worldwide in distribution, affecting all racial and ethnic groups. The prevalence of hemophilia A is approximately 1 in 10,000 males, and that of hemophilia B is 1 in 30,000 males.
The disorder was recognized (although not named) in Babylonian...
This section contains 1,398 words (approx. 5 pages at 300 words per page) |
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