Crystallography is the study of materials in which the atoms stack in a three-dimensionally ordered geometric arrangement. In a single crystal a single pattern extends throughout the entire material. A particular variant of crystallography, x-ray crystallography is the study and determination of crystalline structures through x-ray diffraction techniques. In 1953, Watson and Crick used x-ray crystallography data gathered by other scientists to confirm their model of the double helical structure of DNA.

Detailed analyses of crystal structures are carried out by X-ray diffraction. In 1912, Max von Laue predicted that the spacing of crystal layers is small enough to diffract light of the appropriate wavelength. William Henry Bragg and his son, William Lawrence Bragg, were awarded the Nobel Prize in chemistry (1915) for their development of crystal structure analysis using X-ray diffraction. The Braggs' found that when X-ray radiation was scattered by a crystalline material both constructive and destructive interference occurred...