The Center on Addiction and Substance Abuse at Columbia University (633 Third Avenue, New York, NY 10017) was established in 1992 as a not-for-profit entity affiliated with the university. It was founded by Joseph A. Califano, Jr., a former secretary of health, education, and welfare in the Carter administration, and Herbert D. Kleber, M.D. CASA has been funded by major grants from the Robert Wood Johnson Foundation, as well as other foundations, private companies, and government agencies. Califano, who has had a long-term interest in substance-abuse problems, was a vigorous advocate of smoking cessation programs when he was a member of the Carter cabinet. In organizing CASA, he assembled a board of directors that includes many prominent people in politics, industry, academia, ADVERTISING, and the media. Kleber, a well-known drug abuse researcher and former deputy director of the...