Citrated calcium carbimide is a mixture of two parts citric acid to one part calcium carbimide; it slows the metabolism of ALCOHOL (ethanol) from acetaldehyde to acetate, so it is used in the treatment of ALCOHOL-ISM. It is also known as calcium cyanamide. As an antidipsotropic—an antialcohol or alcohol-sensitizing medication, it has been used for treatment in Canada, the United Kingdom, and Europe since its introduction for clinical use in 1956. Its only therapeutic use is for the treatment of alcoholism. In Canada it is sold under the brand name Temposil. As of 2000, however, calcium carbimide is still not approved for use in the United States.

Pharmacology

The PHARMACOKINETIC data on the absorption metabolism and elimination of carbimide in humans are incomplete. Since nausea, headache, and vomiting occur because of the rapid absorption of carbimide, for treatment purposes it is formulated as a slow-release tablet. Peak...