Lottie May is an innocent young black woman who is the sister of George. She is falsely arrested by Buddy Matlow for prostitution and is forced to have sex with him. As a result of his use of snakes to frighten her, Lottie begins to hallucinate, seeing snakes everywhere. She speaks with Beeder, who is insane, and Beeder tells her to always carry a razor and to kill that which bothers her. Lottie May takes this piece of advice, and when Buddy picks her up again, she castrates him. She casually returns to Beeder, informs her of her deed, and the two talk casually of beating their fears. At the end of the novel, Joe Lon believes he sees Lottie May with Beeder, watching him.