What is the main conflict in Wise Blood by Flannery O'Connor?

The story of a man named Hazel Motes, who denies his Christianity and takes desperate measures to prove his disbelief, Flannery O'Connor's Wise Blood made its debut in 1952. Harcourt Brace published the novel right after O'Connor spent a difficult winter suffering from symptoms that doctors later diagnosed as systemic lupus erythematosus. Critics concur that the disease greatly affected O'Connor's life and work, while they question the specific effects it had on her fiction. Many think that O'Connor's use of the grotesque arose from her own experiences with a disease-ravaged body, yet the general consensus is that O'Connor's religious southern upbringing was the most important influence on her writing.