What is the most important setting in the novel, Then She Was Gone?

Noelle's guest bedroom is the most important setting within the novel. It is the room in which Ellie spends the final year-and-a-half of her life, hoping beyond hope that she might one day be reunited with her family. This is the room in which Noelle drugs and inseminates her. This bedroom is where Ellie feeds and nurtures Poppy within her womb, and where she eventually gives birth to her. It is in this room that Ellie also eventually dies.