The setting for the novel are various places on the island of Sicily for the most part. Palermo is the major city on the island of Sicily. It is where Inspector Velardi and other government officials have their offices. It is where the cathedral is located that the cardinal was kidnapped from. The Hotel Umberto is located in Palermo. This is the hotel that is owned by Don Croce and is where the meeting with Michael Corleone and later the meeting with the Mafia chiefs is held.