What are the motifs in The Heretic's Daughter: A Novel by Kathleen Kent?

Throughout the book, the reader is aware of the story unfolding within a family network. The narrator, Sarah, cares for the infant child Hannah who is a constant presence in her life, as are her brothers. When the smallpox epidemic threatens the Carrier family, all except the father go to stay with Aunt Mary and Uncle Roger in Andover. There, Sarah strengthens her bonds with her cousin Margaret, who is two years older than she. During their stay of several months, Sarah comes to feel an uneasy sense of Alienation from her nuclear family and from her home.