Self-medication is another theme in this book. Throughout her adolescence, Wurtzel is plagued with depression. She is not diagnosed with a particular type of depression, however, and her lack of clarity on the specific diagnosis causes her a lot of uncertainty.
One of the ways that Wurtzel is able to control her depression, her moods and her overall unhappiness is through self-medication. Although she often does not actively seek a solution to self-medicate her depression, she will use a variety of methods to help alleviate her unhappiness. For example, she will often move from one location to another in order to "kick" the problem of her depression.