What is the main conflict in One Hundred Years of Solitude by Gabriel Garcia Marquez?

In the mid-1960s, journalist and fiction writer Gabriel Jose Garcia Marquez was little known outside his native Colombia, having never sold more than seven hundred copies of a book. Everything changed, however, after he had a sudden insight while driving his family through Mexico. In an instant, he saw that the key to the imaginary village of Macondo he had been creating in short vignettes was the storytelling technique of his grandmother—absolute brick-faced description of extraordinary events. He turned the car around and drove straight home, where he proceeded directly to a back room.