The novel has two settings. The first is America, which is a setting that includes not only Jane's home in New York but the many locations at which Jane and her crew film the reality show, My American Wife! This setting takes the reader from the urban area where Jane has her apartment to rural parts of the south and southwest, as well as the churches and clubs that her housewives attend. The other setting of this novel is Japan. Akiko lives in an unnamed city in Japan that is several hours outside Tokyo. This setting is mostly centered on Akiko's apartment and the small world she inhabits as the wife of John Ueno.