One of the subtle yet very important ideas in "Changes: A Love Story" concerns friendship, and the focus of this theme is on the friendship between Esi and Opokuya, though other friendships also play a role in this novel. No one is as different as Opokuya and Esi, but they have been close friends for so long that they are nearly sisters. At the Hotel Twentieth Century, Esi and Opokuya run into one another, and they are excited since they have been out of touch for weeks. As they discuss the fact that Esi has left Oko, Opokuya is sorry for the failure of Esi's marriage.