Sex runs through Cakes and Ale on two levels. First, there is an ongoing debate among artistic types whether marriage interferes with the muse. In any event, wives are resented at literary occasions but invited out of obligation, and the tension is uncomfortable for all.
The second level focuses on Rosie Gann, a barmaid at the seedy Railway Arms in Blackstable, England. She has already gained a reputation for more than talking with customers when "Lord George" Kemp drops in for a drink and begins pursuing her.