One of the major themes of Brothers and Keepers is escape. One of the brothers is always looking for an escape. When John was a child, he began his escape through good grades and sports. He earned a scholarship to the University of Pennsylvania, and thereby escaped the ghetto. Then he escaped again to Laramie, Wyoming, a safe town of white people in the West. John constantly looked for an escape growing up and he found it. But escape comes with consequences.