Peter C. Doherty (Australia) for the epochal discovery of MHC Restriction of T-cell Recognition and the Single T-cell receptor Altered-Self Hypothesis. Jack L. Strominger for pioneering the isolation of and solution to the structures of Class I and Class II MHC proteins and their peptide complexes. Emil R. Unanue for seminal discoveries in antigen processing and MHC-peptide binding which deciphered the biochemical basis of T-cell recognition. Don C. Wiley for visualizing the three-dimensional structures of Class I and Class II proteins and their complexes with antigens and superantigens. Rolf M. Zinkernagal for the landmark discovery of MHC Restriction of T-cell Recognition, and the Altered-Self Hypothesis.