There are two main characters; George and Lennie. Lennie is a big, tall guy, while George is a small guy. Lennie has a mental problem and always confides in George. The two of them are always together. George and Lennie both have a dream of buying and owning a farm where they will have many animals such as puppies and rabbits. They both go to the nearby ranch where George explains that Lennie is his cousin and quietly tell George to let him do all the talking.

Shortly after getting the job, they meet a character by the name of Candy. Candy is a handyman. He had a missing hand and a dog. Then there's Curly, the boss's son. No one is a big fan of his. Because Curly was just married, he is not very jealous of his wife. She is a beautiful lady and he refuses...