"Everyone in the world has a dream he knows can't come off but he spends his life hoping it may. This is at once the sadness, the greatness, and the triumph of our species," novelist John Steinbeck wrote about the major theme of his novel Of Mice and Men. In director Gray Sinise's Screen adaptation of Steinbeck's tragic novel, George Milton (Gray Sinise) travels with Lennie Small (John Malkovich) and takes care of him because Lennie is some kind of retarded. After they escape form Wood, where Lennie touched a girl's dress and get into trouble, they move to another place and find a job in a ranch. They start to work hard because of their dream of having their own ranch. When Candy (Ray Walston), an old ranch hand who lost his left hand in an accident, hears about their dream, he wants to join into it...