growths would be obtained. [Footnote:  This prediction is fully carried out in the present day successful use of considerable amounts of blood in cultures and the resultant frequent demonstrations of bacteria present in the circulation in many infections.—­ Translator.] In the many experiments I have made on the blood in chicken-cholera, I have frequently demonstrated that repeated cultures from droplets of blood do not show an even development even where taken from the same organ, the heart for example, and at the moment when the parasite begins its existence in the blood, which can easily be understood.  Once even, it happened that only three out of ten chickens died after inoculation with infectious blood in which the parasite had just began to appear, the remaining seven showed no symptoms whatever.  In fact, the microbe, at the moment of beginning its entrance into the blood may exist singly or in minute numbers in one droplet and not at all in its immediate neighbor.  I believe therefore that it would be extremely instructive in furunculosis, to find a patient willing to submit to a number of punctures in different parts of the body away from formed or forming furuncles, and thus secure many cultures, simultaneous of otherwise, of the blood of the general circulation.  I am convinced that among them would be found growths of the micro-organism of furuncles.

II.  On Osteomyelitis.  Single observation.  I have but one observation relating to this severe disease, and in this Dr. Lannelongue took the initiative.  The monograph on osteomyelitis published by this learned practitioner is well known, with his suggestion of the possibility of a cure by trephining the bone and the use of antiseptic washes and dressings.  On the fourteenth of February, at the request of Dr. Lannelongue I went to the Sainte-Eugenie hospital, where this skillful surgeon was to operate on a little girl of about twelve years of age.  The right knee was much swollen, as well as the whole leg below the calf and a part of the thigh above the knee.  There was no external opening.  Under chloroform, Dr. Lannelongue made a long incision below the knee which let out a large amount of pus; the tibia was found denuded for a long distance.  Three places in the bone were trephined.  From each of these, quantities of pus flowed.  Pus from inside and outside the bone was collected with all possible precautions and was carefully examined and cultivated later.  The direct microscopic study of the pus, both internal and external, was of extreme interest.  It was seen that both contained large numbers of the organism similar to that of furuncles, arranged in pairs, in fours and in packets, some with sharp clear contour, others only faintly visible and with very pale outlines.  The external pus contained many pus corpuscles, the internal had none at all.  It was like a fatty paste of the furuncular organism.  Also, it may be noted, that growth of the small organism had begun in less than six hours after the cultures were started.