When the scab is prematurely rubbed off (a circumstance not unfrequent among children and working people), the application of a little aqua lythargyri acet. to the part immediately coagulates the surface, which supplies its place, and prevents a sore.
In my former treatises on this subject I have remarked that the human constitution frequently retains its susceptibility to the smallpox contagion (both from effluvia and contact) after previously feeling its influence. In further corroboration of this declaration many facts have been communicated to me by various correspondents. I shall select one of them.
“Dear sir:
“Society at large must, I think, feel much indebted
to you for your Inquiries and Observations on the
Nature and Effects of the Variolae Vaccinae, etc.,
etc. As I conceive what I am now about to
communicate to be of some importance, I imagine it
cannot be uninteresting to you, especially as it will
serve to corroborate your assertion of the susceptibility
of the human system of the variolous contagion, although
it has previously been made sensible of its action.
In November, 1793, I was desired to inoculate a person
with the smallpox. I took the variolous matter
from a child under the disease in the natural way,
who had a large burthen of distinct pustules.
The mother of the child being desirous of seeing my
method of communicating the disease by inoculation,
after having opened a pustule, I introduced the point
of my lancet in the usual way on the back part of my
own hand, and thought no more of it until I felt a
sensation in the part which reminded me of the transaction.
This happened upon the third day; on the fourth there
were all the appearances common to inoculation, at
which I was not at all surprised, nor did I feel myself
uneasy upon perceiving the inflammation continue to
increase to the sixth and seventh day, accompanied
with a very small quantity of fluid, repeated experiments
having taught me it might happen so with persons who
had undergone the disease, and yet would escape any
constitutional affection; but I was not so fortunate;
for on the eighth day I was seized with all the symptoms
of the eruptive fever, but in a much more violent degree
than when I was before inoculated, which was about
eighteen years previous to this, when I had a considerable
number of pustules. I must confess I was now
greatly alarmed, although I had been much engaged
in the smallpox, having at different times inoculated
not less than two thousand persons. I was convinced
my present indisposition proceeded from the insertion
of the variolous matter, and, therefore, anxiously
looked for an eruption. On the tenth day I felt
a very unpleasant sensation of stillness and heat
on each side of my face near my ear, and the fever
began to decline. The affection in my face soon
terminated in three or four pustules attended with
inflammation, but which did not maturate, and I was
presently well.
“I remain,
dear sir, etc.,
“Thomas
miles.”