7th:  The inflammation began to advance.

8th:  A vesication, perceptible on the edges, forming, as in the inoculated smallpox, an appearance not unlike a grain of wheat, with the cleft, or indentation in the centre.

9th:  Pain in the axilla.

10th:  A little headache; pulse, 110; tongue not discoloured; countenance in health.

11th, 12th:  No perceptible illness; pulse about 100.

13th:  The pustule was now surrounded by an efflorescence, interspersed with very minute confluent pustules to the extent of about an inch.  Some of these pustules advanced in size and maturated.  So exact was the resemblance of the arm at this stage to the general appearance of the inoculated smallpox that Mr. D., a neighbouring surgeon, who took some matter from it, and who had never seen the cow-pox before, declared he could not perceive any difference. [Footnote:  That the cow-pox was a supposed guardian of the constitution from the action of the smallpox has been a prevalent idea for a long time past; but the similarity in the constitutional effects between one disease and the other could never have been so accurately observed had not the inoculation of the cow-pox placed it in a new and stronger point of view.  This practice, too, has shewn us, what before lay concealed, the rise and progress of the pustule formed by the insertion of the virus, which places in a most conspicuous light its striking resemblance to the pustule formed from the inoculated smallpox.] The child’s arm now shewed a disposition to scab, and remained nearly stationary for two or three days, when it began to run into an ulcerous state, and then commenced a febrile indisposition accompanied with an increase of axillary tumour.  The ulcer continued spreading near a week, during which time the child continued ill, when it increased to a size nearly as large as a shilling.  It began now to discharge pus; granulations sprang up, and it healed.  This child had before been of a remarkably sickly constitution, but is now in very high health.

Mary Hearn, twelve years of age, was inoculated with matter taken from the arm of Susan Phipps.

6th day:  A pustule beginning to appear, slight pain in the axilla.

7th:  A distinct vesicle formed.

8th:  The vesicle increasing; edges very red; no deviation in its appearance at this time from the inoculated smallpox.

9th:  No indisposition; pustule advancing.

10th:  The patient felt this evening a slight febrile attack.

11th:  Free from indisposition.

12th, 13th:  The same.

14th:  An efflorescence of a faint red colour extending several inches round the arm.  The pustule, beginning to shew a disposition to spread, was dressed with an ointment composed of hydrarg. nit. rub. and ung. cerce.  The efflorescence itself was covered with a plaster of ung. hydr. fort.  In six hours it was examined, when it was found that the efflorescence had totally disappeared.