Case XVIII.—­John Baker, a child of five years old, was inoculated March 16, 1798, with matter taken from a pustule on the hand of Thomas Virgoe, one of the servants who had been infected from the mare’s heels.  He became ill on the sixth day with symptoms similar to those excited by cow—­pox matter.  On the eighth day he was free from indisposition.

There was some variation in the appearance of the pustule on the arm.  Although it somewhat resembled a smallpox pustule, yet its similitude was not so conspicuous as when excited by matter from the nipple of the cow, or when the matter has passed from thence through the medium of the human subject.

This experiment was made to ascertain the progress and subsequent effects of the disease when thus propagated.  We have seen that the virus from the horge, when it proves infectious to the human subject, is not to be relied upon as rendering the system secure from variolous infection, but that the matter produced by it upon the nipple of the cow is perfectly so.  Whether its passing from the horse through the human constitution, as in the present instance, will produce a similar effect, remains to be decided.  This would mow have been effected, but the boy was rendered unit for inoculation from having felt the effects of a contagious fever in a workhouse soon after this experiment was made.

Case XIX.—­William Summers, a child of five years and a half old, was inoculated the same day with Baker, with matter taken from the nipples of one of the infected cows, at the farm alluded to.  He became indisposed on the sixth day, vomited once, and felt the usual slight symptoms till the eighth day, when he appeared perfectly well.  The progress of the pustule, formed by the infection of the virus, was similar to that noticed in Case XVII, with this exception, its being free from the livid tint observed in that instance.

Case xx.-From William Summers the disease was transferred to William Pead, a boy of eight years old, who was inoculated March 28th.  On the sixth day he complained of pain in the axilla, and on the seventh was affected with the common symptoms of a patient sickening with the smallpox from inoculation, which did not terminate till the third day after the seizure.  So perfect was the similarity to the variolous fever that I was induced to examine the skin, conceiving there might have been some eruptions, but none appeared.  The efflorescent blush around the part punctured in the boy’s arm was so truly characteristic of that which appears on variolous inoculation that I have given a representation of it.  The drawing was made when the pustule was beginning to die away and the areola retiring from the centre.