On the seventh day he complained of uneasiness in the axilla, and on the ninth he became a little chilly, lost his appetite, and had a slight headache.  During the whole of this day he was perceptibly indisposed, and spent the night with some degree of restlessness, but on the day following he was perfectly well.

The appearance of the incisions in their progress to a state of maturation were much the same as when produced in a similar manner by variolous matter.  The only difference which I perceived was in the state of the limpid fluid arising from the action of the virus, which assumed rather a darker hue, and in that of the efflorescence spreading round the incisions, which had more of an erysipelatous look than we commonly perceive when variolous matter has been made use of in the same manner; but the whole died away (leaving on the inoculated parts scabs and subsequent eschars) without giving me or my patient the least trouble.

In order to ascertain whether the boy, after feeling so slight an affection of the system from the cow—­pox virus, was secure from the contagion of the smallpox, he was inoculated the 1st of July following with variolous matter, immediately taken from a pustule.  Several slight punctures and incisions were made on both his arms, and the matter was carefully inserted, but no disease followed.  The same appearances were observable on the arms as we commonly see when a patient has had variolous matter applied, after having either the cow—­pox or smallpox.  Several months afterwards he was again inoculated with variolous matter, but no sensible effect was produced on the constitution.

Here my researches were interrupted till the spring of the year 1798, when, from the wetness of the early part of the season, many of the farmers’ horses in this neighbourhood were affected with sore heels, in consequence of which the cow—­pox broke out among several of our dairies, which afforded me an opportunity of making further observations upon this curious disease.

A mare, the property of a person who keeps a dairy in a neighbouring parish, began to have sore heels the latter end of the month of February, 1798, which were occasionally washed by the servant men of the farm, Thomas Virgoe, William Wherret, and William Haynes, who in consequence became affected with sores in their hands, followed by inflamed lymphatic glands in the arms and axillae, shiverings succeeded by heat, lassitude, and general pains in the limbs.  A single paroxysm terminated the disease; for within twenty—­four hours they were free from general indisposition, nothing remaining but the sores on their hands.  Haynes and Virgoe, who had gone through the smallpox from inoculation, described their feelings as very similar to those which affected them on sickening with that malady.  Wherret never had had the smallpox.  Haynes was daily employed as one of the milkers at the farm, and the disease began to shew itself among the cows about ten days after he first assisted in washing the mare’s heels.  Their nipples became sore in the usual way, with bluish pustules; but as remedies were early applied, they did not ulcerate to any extent.