The King, having been thus artfully inflamed against his brother and his unfortunate secretary, became clamorous for the blood of Escovedo.  At the same time, that personage, soon after his return to Spain, was shocked by the discovery of the amour of Perez with the Princess Eboli.  He considered it his duty, both towards the deceased Prince and the living King, to protest against this perfidy.  He threatened to denounce to the King, who seemed the only person about the court ignorant of the affair, this double treason of his mistress and his minister.  Perez and Anna of Eboli, furious at Escovedo’s insolence, and anxious lest he should execute his menace determined to disembarrass themselves of so meddlesome a person.  Philip’s rage against Don John was accordingly turned to account, and Perez received the King’s secret orders to procure Escovedo’s assassination.  Thus an imaginary conspiracy of Don John against, the crown of Philip was the pretext, the fears and rage of Eboli and her paramour were the substantial reason, for the crime now projected.

The details of the murder were arranged and executed by Perez, but it must be confessed in justice to Philip, with much inferior nicety to that of his, own performances in the same field.  Many persons were privy to the plot.  There was much blundering, there was great public scandal in Madrid, and no one ever had a reasonable doubt as to the instigators and the actual perpetrators of the crime.  Two attempts to poison Escovedo were made by Perez, at his own table, through the agency of Antonio Enriquez, a confidential servant or page.  Both were unsuccessful.  A third was equally so, but suspicions were aroused.  A female slave in the household of Escovedo, was in consequence arrested, and immediately hanged in the public square, for a pretended attempt to murder her master.  A few days afterwards (on the 31st of March, 1578) the deed was accomplished at nightfall in the streets of Madrid, by six conspirators.  They consisted of the majordomo of Perez, a page in his household, the page’s brother from the country, an ex-scullion from the royal kitchens, Juan Rubio by name, who had been the unsuccessful agent in the poisoning scheme, together with two professional bravos, hired for the occasion.  It was Insausti, one of this last-mentioned couple, who despatched Escovedo with a single stab, the others aiding and abetting, or keeping watch in the neighbourhood.

The murderers effected their escape, and made their report to Perez, who for the sake of appearances, was upon a visit in the country.  Suspicion soon tracked the real culprits, who were above the reach of justice; nor, as to the motives which had prompted the murders, were many ignorant, save only the murderer himself.  Philip had ordered the, assassination; but he was profoundly deceived as to the causes of its accomplishment.  He was the dupe of a subtler villain than himself, and thought himself sacrificing a conspirator against his crown, while he had really only crushed a poor creature who had been but too solicitous for what he thought his master’s honor.