The years which followed this brilliantly disastrous opening brought little good to France. In 1516 the death of Ferdinand the Catholic placed Charles on the throne of Spain; in 1519 the death of Maximilian threw open to the young Princes the most dazzling prize of human ambition,—the headship of the Holy Roman Empire. Francois I., Charles, and Henry VIII. were all candidates for the votes of the seven electors, though the last never seriously entered the lists. The struggle lay between Francois, the brilliant young Prince, who seemed to represent the new opinions in literature and art, and Charles of Austria and Spain, who was as yet unknown and despised, and, from his education under the virtuous and scholastic Adrian of Utrecht, was thought likely to represent the older and reactionary opinions of the clergy. After a long and sharp competition, the great prize fell to Charles, henceforth known to history as that great monarch and emperor, Charles V.
The rivalry between the Princes could not cease there. Charles, as representative of the House of Burgundy, claimed all that had been lost when Charles the Bold fell; and in 1521 the war broke out between him and Francois, the first of a series of struggles between the two rivals. While the King wasted the resources of his country on these wars, his proud and unwise mother, Louise of Savoy, guided by Antoine du Prat, ruled, to the sorrow of all, at home. The war brought no glory with it: on the Flemish frontier a place or two was taken; in Biscay Fontarabia fell before the arms of France; in Italy Francois had to meet a new league of Pope and Emperor, and his troops were swept completely out of the Milanese. In the midst of all came the defection of that great prince, the Constable de Bourbon, head of the younger branch of the Bourbon House, the most powerful feudal lord in France. Louise of Savoy had enraged and offended him, or he her; the King slighted him, and in 1523 the Constable made a secret treaty with Charles V. and Henry VIII., and, taking flight into Italy, joined the Spaniards under Lannoy. The French, who had again invaded the Milanese, were again driven out in 1524; on the other hand, the incursions