As soon as his three eldest boys, Giacomo, Cristoforo, and Rocco, were out of their tutors’ hands, in order to get rid of them he sent them to the University of Salamanca, where, out of sight, they were out of mind, for he thought no more about them, and did not even send them the means of subsistence.  In these straits, after struggling for some months against their wretched plight, the lads were obliged to leave Salamanca, and beg their way home, tramping barefoot through France and Italy, till they made their way back to Rome, where they found their father harsher and more unkind than ever.

This happened in the early part of the reign of Clement viii, famed for his justice.  The three youths resolved to apply to him, to grant them an allowance out of their father’s immense income.  They consequently repaired to Frascati, where the pope was building the beautiful Aldobrandini Villa, and stated their case.  The pope admitted the justice of their claims, and ordered Francesco, to allow each of them two thousand crowns a year.  He endeavoured by every possible means to evade this decree, but the pope’s orders were too stringent to be disobeyed.

About this period he was for the third time imprisoned for infamous crimes.  His three sons them again petitioned the pope, alleging that their father dishonoured the family name, and praying that the extreme rigour of the law, a capital sentence, should be enforced in his case.  The pope pronounced this conduct unnatural and odious, and drove them with ignominy from his presence.  As for Francesco, he escaped, as on the two previous occasions, by the payment of a large sum of money.

It will be readily understood that his sons’ conduct on this occasion did not improve their father’s disposition towards them, but as their independent pensions enabled them to keep out of his way, his rage fell with all the greater intensity on his two unhappy daughters.  Their situation soon became so intolerable, that the elder, contriving to elude the close supervision under which she was kept, forwarded to the pope a petition, relating the cruel treatment to which she was subjected, and praying His Holiness either to give her in marriage or place her in a convent.  Clement viii took pity on her; compelled Francesco Cenci to give her a dowry of sixty thousand crowns, and married her to Carlo Gabrielli, of a noble family of Gubbio.  Francesco driven nearly frantic with rage when he saw this victim released from his clutches.

About the same time death relieved him from two other encumbrances:  his sons Rocco and Cristoforo were killed within a year of each other; the latter by a bungling medical practitioner whose name is unknown; the former by Paolo Corso di Massa, in the streets of Rome.  This came as a relief to Francesco, whose avarice pursued his sons even after their death, far he intimated to the priest that he would not spend a farthing on funeral services.  They were accordingly borne to the paupers’ graves which he had caused to be prepared for them, and when he saw them both interred, he cried out that he was well rid of such good-for-nothing children, but that he should be perfectly happy only when the remaining five were buried with the first two, and that when he had got rid of the last he himself would burn down his palace as a bonfire to celebrate the event.