During these events in Lombardy, the pope sent Lorenzo to invest Citta di Castello, for the purpose of expelling Niccolo Vitelli, the place having been abandoned to him by the League, for the purpose of inducing the pontiff to join them.  During the siege, Niccolo’s troops were led out against the papal forces and routed them.  Upon this the pope recalled the Count Girolamo from Lombardy with orders first to recruit his army at Rome, and then proceed against Citta di Castello.  But thinking afterward, that it would be better to obtain Niccolo Vitello as his friend than to renew hostilities with him, an arrangement was entered into by which the latter retained Citta di Castello, and the pope pacified Lorenzo as well as he could.  He was induced to both these measures rather by his apprehension of fresh troubles than by his love of peace, for he perceived dissensions arising between the Colonessi and the Orsini.

In the war between the king of Naples and the pope, the former had taken the district of Tagliacozzo from the Orsini, and given it to the Colonnesi, who had espoused his cause.  Upon the establishment of peace, the Orsini demanded its restoration by virtue of the treaty.  The pope had frequently intimated to the Colonnesi that it ought to be restored; but they, instead of complying with the entreaties of the Orsini, or being influenced by the pope’s threats, renewed hostilities against the former.  Upon this the pontiff, unable to endure their insolence, united his own forces with those of the Orsini, plundered the houses they possessed in Rome, slew or made prisoners all who defended them, and seized most of their fortresses.  So that when these troubles were composed, it was rather by the complete subjugation of one party than from any desire for peace in the other.

Nor were the affairs of Genoa or of Tuscany in repose, for the Florentines kept the Count Antonio da Marciano on the borders of Serezana; and while the war continued in Lombardy, annoyed the people of Serezana by inroads and light skirmishes.  Battistino Fregoso, doge of Genoa, trusting to Pagolo Fregoso, the archbishop, was taken prisoner, with his wife and children, by the latter, who assumed the sovereignty of the city.  The Venetian fleet had attacked the kingdom of Naples, taken Gallipoli, and harassed the neighboring places.  But upon the peace of Lombardy, all tumults were hushed except those of Tuscany and Rome; for the pope died in five days after its declaration, either in the natural course of things, or because his grief for peace, to which he was always opposed, occasioned his end.