Brought up from infancy amidst snares, intrigues, the clash of arms, the furious shouts of popular insurrections, tempests, and storms, she could not escape the influence of her early environment. Her talent for studying and penetrating the designs of her enemies, for facing or avoiding dangers with such sublime calmness and prudence, was partly inherited, partly acquired. That spirit she took with her to France, where her experience was widened and her opportunities for the study of human nature were increased.
It is not generally known that her mother was a French woman—a Madeleine de La Tour d’Auvergne, daughter of Jean, Count of Boulogne, and Catherine of Bourbon, daughter of the Count of Vendome; thus, her gentler nature was a French product. Her mother and father both died when she was but twenty-two days old, and from that time until her marriage she was cast about from place to place. But from the very first she showed that talent of adapting herself to her surroundings, living amidst intrigues and discords and yet making friends. She has been called “the precocious heiress of the craftiness of her progenitors.”
In her thirteenth year, after being sought by many powerful princes, Clement VII. (her greatuncle), in order to secure himself against the powerful Charles V., married her to Henry, Duke of Orleans, the second son of Francis I. Even at that early age she was fully aware of all the dreariness and danger attached to positions of power, and knew that the art of governing was not an easy one. She had studied Machiavelli’s famous work, The Prince, which had been dedicated to her father, and it was from it, as well as from her ancestors, that she derived her wisdom and astuteness. Her childhood had prepared her for the work of the future, and she went at it with caution and reserve until she was sure of her ground.
She first proceeded to study the king, Francis I., watching his actions, extracting his secrets; a fine huntress and at his side constantly, she pleased him and gained his favor. Brantome says she was subtle and diplomatic, quickly learning the craft of her profession; she sought friends among all classes and ranks, directing her overtures specially toward the ladies of the court, whom she soon won and gathered about her.