The revolt of Arsaces has been placed by some as early as the year B.C. 256. The Bactrian revolt is assigned by most historians to that year; and the Parthian, according to some, was contemporary. The best authorities, however, give a short interval between the two insurrections; and, on the whole, there is perhaps reason to regard the Parthian independence as dating from about B.C. 250. This year was the eleventh of Antiochus Theus, and fell into the time when he was still engaged in his war with Ptolemy Philadelphus. It might have been expected that when he concluded a peace with the Egyptian monarch in B.C. 249, he would have turned his arms at once towards the east, and have attempted at any rate the recovery of his lost dominions. But, as already stated, his personal character was weak, and he preferred the pleasures of repose at Antioch to the hardships of a campaign in the Caspian region. So far as we hear, he took no steps to re-establish his authority; and Arsaces, like Diodotus, was left undisturbed to consolidate his power at his leisure.
Arsaces lived, however, but a short time after obtaining the crown. His authority was disputed within the limits of Parthia itself; and he had to engage in hostilities with a portion of his own subjects. We may suspect that the malcontents were chiefly, if not solely, those of Greek race, who may have been tolerably numerous, and whose strength would lie in the towns. Hecatompylos, the chief city of Parthia, was among the colonies founded by Alexander; and its inhabitants would naturally be disinclined to acquiesce in the rule of a “barbarian.” Within little more than two years of his coronation, Arsaces, who had never been able to give his kingdom peace, was killed in battle by a spear-thrust in the side; and was succeeded (B.C. 247) by his brother, having left, it is probable, no sons, or none of mature age.