But to engage in so great a matter with a good prospect of success it was necessary that the war should be approved, not only by himself, but by his principal feudatories. The most important of these was now Izates, king of Adiabene and Gordyene who in the last reign had restored Artabanus to his lost throne. Vardanes, before committing himself by any overt act, appears to have taken this prince into his counsels, and to have requested his opinion on affronting the Romans by an interference with Armenian affairs. Izates strenuously opposed the project. He had a personal interest in the matter, since he had sent five of his boys to Rome, to receive there a polite education, and he had also a profound respect for the Roman power and military system. He endeavored, both by persuasion and reasoning, to induce Vardanes to abandon his design. His arguments may have been cogent, but they were not thought by Vardanes to have much force, and the result of the conference was that the Great King declared war against his feudatory.
The war had, apparently, but just begun, when fresh troubles broke out in the north-east. Gotarzes had never ceased to regret his renunciation of his claims, and was now, on the invitation of the Parthian nobility, prepared to came forward again and contest the kingdom with his brother. Vardanes had to relinquish his attempt to coerce Izates, and to hasten to Hyrcania in order to engage the troops which Gotarzes had collected in that distant region. These he met and defeated more than once in the country between the Caspian and Herat; but the success of his military operations failed to strengthen his hold upon the affections of his subjects. Like the generality of the Parthian princes, he showed himself harsh and cruel in the hour of victory, and in conquering an opposition roused an opposition that was fiercer and more formidable. A conspiracy was formed against him shortly after his return from Hyrcania, and he was assassinated while indulging in the national amusement of the chase.